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Archive for the 'Botanicals' Category

St. John’s Wort and Oral Contraceptives

Sixteen healthy women who had taken a low dose oral contraceptive (OC) with 20 mcg ethinylestradiol + 0.15 mg desogesterol for at least 3 months participated in this study. A 50% ethanol extract of St. John’s wort 250 mg twice daily standardized to 0.2% hypericin (1 mg/day) and < 0.2%(< 1mg/day) hyperforin was initiated day [...]

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A small randomized, double-blind, placebo-controlled, crossover trial of fourteen postmenopausal women was completed using 3.5 gm of powdered Maca (Lepidium meyenii) for 6 weeks and matching placebo for 6 weeks. Measurements of estradiol, follicle-stimulating hormone (FSH), luteinizing hormone (LH), and sex hormone binding globulin (SHBG) were taken at baseline, and weeks 6 and 12. [...]

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Thirty-two hirsute women with polycystic ovary syndrome (PCOS) were studied in an open-label clinical trial. All the women were given 100 mg of spironolactone per day while sixteen of them also received 3.5 g/day of a licorice root extract standardized to 7.6% glycyrrhetinic acid. Study duration was two months. Systolic blood pressure significantly decreasd at [...]

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Good news for green tea and genital warts

In order to evaluate the efficacy of a topical green tea extract, researchers conducted a randomized, double-blind, vehicle (placebo)-controlled trial involving 502 men and women aged 18 and older. Participants were clinically diagnosed with 2 to 30 external genital and perianal warts and were randomly assigned to receive sinecatechins ointment 15%, sinecatechins ointment 10% [...]

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Saffron in the treatment of PMS

The objective of this double-blind, placebo-controlled trail was to study whether saffron could be used to relieve PMS symptoms. 50 reproductive aged women with regular menstrual cycles and with PMS symptoms for at least the last 6 months were randomly assigned to receive 15 mg of saffron twice daily, or placebo twice daily, for four [...]

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This randomized, double-blind, controlled 3-month study in China enrolled 244 menopausal women aged 40-60. Women were assigned to either an isopropanolic extract of Black Cohosh containing 40 mg/day or one 2.5 mg tibolone tablet per day, a drug known to reduce hot flashes.
Results: There was a significant trend (57.8%) that women given [...]

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This was a prospective, non-randomized, open-label observational study conducted over two years, in Germany. The purpose of the study was to evaluate the use, safety and effectiveness of black cohosh alone or in combination with St. John’s wort on menopausal symptoms.
6141 women at 1287 outpatient gynecology offices were treated with recommended doses of black [...]

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This population-based cased-control study in Philadelphia consisted of 949 breast cancer cases and 1,524 controls. Herbal supplements including black cohosh, ginseng and red clover were the most prevalent preparations. After adjusting for potential confounding factors, black cohosh use was associated with a 61 percent reduction in the risk of breast cancer with an [...]

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Women account for about three quarters of the 28 million Americans who experience migraine headaches. Migraines can begin at any age, and occur fairly equally in boys and girls until adolescence. The prevalence of migraines in women in their early forties, and then declines steadily with age.
How does a migraine occur?
The process resulting in a [...]

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Rebbeck T, Troxel A, Norman S, et al. A retrospective case-control study of the use of hormone-related supplements and association with breast cancer. Int. J. Cancer 2006; 120:1523-1528.
This population-based cased-control study in Philadelphia consisted of 949 breast cancer cases and 1,524 controls. Herbal supplements including Black Cohosh, ginseng and red clover were [...]

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